Truce–Smiles Rearrangements by Strain Release: Harnessing Primary Alkyl Radicals for Metal?Free Arylation
نویسندگان
چکیده
The ring-opening of 3-aminocyclobutanone oximes enables easy generation primary alkyl radicals, capable undergoing an unprecedented strain-release, desulfonylative radical Truce–Smiles rearrangement, providing divergent access to valuable 1,3 diamines and unnatural ?-amino acids. Characterized by mild conditions wide scope migrating species, this protocol allows the modular assembly sp3-aryls under transition metal-free, room-temperature conditions.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2021
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/anie.202108240